Though biopunk is not the primary setting, the bioshock series’ plasmids and vigors cast enough of that genre in there for me, with Infinite being one of my favorite FPS games. If you don’t wanna count that, well Resident Evil 4 is another favorite of mine, and an entire series of mutant virii and evil parasites turning people into organic weapons has got to count

I think Cruelty Squad counts as biopunk. It’s really, really crusty biopunk, but still biopunk. I mean, you can get your appendix modified to work as a grappling hook, you can get holes drilled in your body that expel waste to either let you double/triple/quadruple jump or launch you forwards.

Haven’t played much in this genre, but loved all of Axiom Verge