AFAIK it all boils down to the fact that during embryonal development our cells, which at that point were just a blob of undifferentiated autonomous chemical machines, somehow managed to unanimously agree upon the cardinal directions (up-down, left-right, front-back) for future development - and thanks to this, we don’t have toes growing out of our ears.
Oh that’s actually a good point, so there are upsides as well.
Movies would also look really silly when someone would get killed by having their nose pinched closed