St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness midkine’s protective power.
They actually aren’t. There was a hypothesis presented in 1992 based on some AD pathology images, but by 2008 in truly unbiased studies, they showed no correlation between amyloid load and disease . Many healthy elderly brains are full of amyloid.
But by then, the Amyloid hypothesis became a religion, and supported by some key manuscripts all later proven to be faked. .
Then biogen made a drug that reduced amyloid by 30% in trials…yet no benefit was actually seen in patients who didn’t die of brain bleeds.
In 2011, the Editor of the Journal of Alzheimers disease died in an accident, and this review was then published, because publishing while he was active would have ended his lab.
“For better or worse, the amyloid cascade hypothesis continues to be a conclusion in search of data. As the hypothesis and its various permutations continue to dominate the literature, the extent to which the scientific community clings to the righteousness of the idea with the passage of time and confrontation of contradictory data is striking. In a different context, such a degree of faith would be the envy of any religion.”
Grok, Chat GPT, etc will tell you about amyloid, because their models are trained on a massive pile of bullshit.
Meanwhile, elderly people who maintain their vaccinations have signficantly less dementia..
You, sir or madam or they, are a hero. That’s exactly the data I couldn’t remember, but is the reason I felt I had to comment.
However many are not, yet IIRC dementia patients always do.