If you have a filament runout sensor, the klipper default settings aren’t great. If the sensor activates, the printer shuts down after about an hour, losing your home position. With a part on the bed, you can’t re-home, so it’s a wasted print.

The mesh leveling isn’t automatic either. You might want to add either auto-load your default mesh leveling if you always use the same print surface, or put mesh leveling codes in the starting G-code section of your slicer.

I ran the pressure advance tuning and found that I needed a ton of pressure advance. My prints turned out much better.

I also got improvements by reducing the allowable deviation in the slicer (G-code files get much bigger, though), and I load files as STEP files directly in Prusaslicer. STL doesn’t have curves, it’s a series of planes. STEP files have geometric primitives and can have curves.